Significant copy number aberrations associated with grade 2–4 and moderately or poorly differentiated HCCs are gain of 1q21.1-q23.2 containing 261 genes including 5 cancer genes BCL9, ARNT, TPM3, MUC1, and NTRK1 and gain of 8q11.1q13.1 containing 76 genes including 3 cancer genes TCEA1, PLAG1, and CHCHD7 (Table 4). Here, BCL9 is linked to cancer.