TNF and Hearing impairment: In the present study, we intended to clarify the relationship between hearing impairment and nine polymorphisms of genes encoding inflammatory mediators, namely, TNF-α C-863A, rs1800630; TNF receptor superfamily member (TNFRSF) 1B G593A, rs1061624; IL-1A -889C/T, rs1800587; IL-1B -511C/T, rs16944; IL-4R G1902A, rs1801275; IL-6 C-572G, also known as C-634G, rs1800796; IL-10 A-592C, rs1800872; IL-1 receptor-associated kinase 1 (IRAK1) T587C, rs1059702; CRP +1444 C > T, rs1130864.