The function of transmitting the signals from cancer cells to the surrounding or distant environment could be performed by protein kinases (CIT, MAP4K4, Yes1, DDR1, WEE1, SRC) and growth factor receptors like MET, which were measured in Paca44 EVs, together with a high number of small G-proteins (ras, rab and ral families). The gene discussed is YES1; the disease is cancer.