NFE2L2 and neoplasm: Recently, it has been reported that NRF2 stability is regulated, through protein-protein interaction to compete with or sterically inhibit KEAP1, by various proteins including p2117, the Wilms tumor gene on X chromosome (WTX)18, p6219, the partner and localizer of BRCA2 (PALB2)20, the dipeptidyl peptidase III (DPP3)21, and the breast cancer susceptibility gene 1 (BRCA1)22.