We tested eight MPS related enzymes, including alpha-L-iduronidase, iduronate-2-sulfatase, heparan sulfate sulfatase, alpha N-acetylglucosaminidase, galactosamine 6-Sulfatase, β-galactosidase, arylsulfatase, β-glucuronidase, which are responsible for different subtypes of MPS (Table 2). Here, NAGLU is linked to mucopolysaccharidosis.