Sequence analysis of 2.5 kb spanning the promoter region to exon1 of the IFNGR1 gene in 24 Japanese individuals, 12 unaffected and 12 atopic dermatitis patients, identified nine polymorphisms, five of which were detected in the promoter region while the other four variants were found in exon 1 [10]. Here, IFNGR1 is linked to atopic eczema.