PNPLA3 and obesity due to melanocortin 4 receptor deficiency: Similarly, we discover PNPLA2 and PNPLA3, for which genetic variations have previously been associated with obesity (Johansson et al. 2008) and non-alcoholic fatty liver disease (Romeo et al. 2008), as the key nodes bridging Triglyceride metabolic process cluster with central regulatory mechanisms.