AFP and hepatocellular carcinoma: Univariate analysis demonstrated that Serum AFP level (P = 0.041), tumor size (P < 0.001), vascular invasion (P = 0.001), histological grade (P = 0.048) and TNM stage (P = 0.004), and miR-106b expression (P = 0.004) were significantly associated with overall survival of HCC patients (Table 2).