Similarly to data in the literature [14, 16, 17] we injected 25 × 104 B16-F10 melanoma cells subcutaneously but found no differences in tumor growth and immune cell subset composition within the tumor when using a global CD73 knockout, an endothelium specific CD73 knockout or a CD73 knockout on hematopoietic cells generated by bone marrow transplantation. The gene discussed is NT5E; the disease is melanoma.