Another randomized trial performed in Haiti found that early ART-initiation (>200 and <350 CD4 T-cells per mm3) compared to ART initiation at a CD4 T-cell count <200 decreased the rates of death by 75% and incident tuberculosis by 50%, leading the WHO to revise ART treatment initiation guidelines from 200 to 350 cells/mm [48]. The gene discussed is CD4; the disease is tuberculosis.