We report here that PLD3, a gene that increases risk of AD (Cruchaga et al., 2014), is required for endosome-to-Golgi retrieval and therefore establish a role for PLD3 in a pathway that is now viewed as key to events early in the pathology of AD (Small, 2008; Willnow and Andersen, 2013). The gene discussed is PLD3; the disease is Alzheimer disease.