APP and Alzheimer disease: EHD1 operates with retromer in endosome-to-Golgi retrieval (Gokool et al., 2007; Zhang et al., 2012), and both EHD1 and Rab11-mediated endosomal protein recycling have recently been shown to regulate localization and processing of APP consistent with the prominent role that endosomal protein sorting plays in AD (Buggia-Prévot et al., 2013; Udayar et al., 2013).