Among these pathways, the PLC signaling pathway has also been reported to play a critical role in mediating Ca2+ signaling in host cells during infection processes of different pathogens by catalyzing phosphatidylinositol-4,5-biphosphate (PIP2) to form inositol-1,4,5-triphosphate (IP3) [38], [58], [59]. Here, HSPG2 is linked to infection.