Thus, the blockade of TREM-1 with a soluble mTREM-1/IgG fusion protein reduces the TREM-1-mediated inflammatory response and the severity of infectious diseases, such as Pseudomonas aeruginosa-related keratitis [10], septic shock [6] and inflammatory bowel disease (IBD) [9], [12]. The gene discussed is TREM1; the disease is infectious disease.