While the results from this study show grey matter thinning of frontal regions bilaterally, a loss of integrity of the superior cerebellar peduncles has also been found in separate studies.[33],[34] Furthermore, previous studies have shown deep grey matter structure degeneration [30] and loss of integrity of various other white matter fibres [30],[34] - it is possible that in degenerative diseases such as PSP, the build-up of subcortical tau deposition is followed by white matter tract degeneration [30],[33] which subsequently causes neuronal loss, reflected by thinning of the cortex. The gene discussed is MAPT; the disease is neurodegenerative disease.