Data obtained in Abcb4/Mdr2−/− (canalicular phospholipid export pump/multidrug resistance protein 2) mice, representing a well characterized model system for sclerosing cholangitis and biliary type of liver fibrosis, suggest potential direct anti-inflammatory and anti-fibrotic effects of norUDCA [6], [12], [13]. The gene discussed is ABCB4; the disease is Hepatic fibrosis.