This disorder is classified as a segmental progeria that arises due to a mutation in ERCC8 and ERCC6. In previous studies, short insertions and deletions, nonsense mutations, splice mutations, missense mutations and promoter mutation have all been implicated in Cockayne’s syndrome, and among the 84 reported cases up to 2009, approximate 65% had mutations in the ERCC6[5], [12]. The gene discussed is ERCC8; the disease is Cockayne syndrome.