SOD2 and lentivirus infection: In Fig. 6a, the mouse endothelial cells (MECs) from the heart and aorta were isolated using Laser Capture Microdissection (LCM) for the mRNA analysis, the results showed that the removal of E2 through OVX surgery significantly decreased the expression of SOD2 by ~2-fold compared to the Sham/CTL mice, the E2 treatment on those OVX mice restored the SOD2 expression, while the SOD2 lentivirus infection of those OVX mice significantly increased SOD2 expression by ~1.6- and ~1.8-fold respectively compared to Sham/CTL mice.