Using human malignant mesothelioma cells (HM) as a model for a ROS-driven tumor cell line [21] we sought to investigate the phenotype associated with lowering expression of the mitochondrial oxidoreductase peroxiredoxin 3 (PRX3), the antioxidant enzyme responsible for metabolizing the majority of mitochondrial peroxide [22]. This evidence concerns the gene PRDX3 and malignant mesothelioma.