EGF and hepatocellular carcinoma: HCV proteins have been shown to interact with well-established cellular pathways, known to be involved in HCC initiation or progression: cell proliferation and differentiation involving epidermal growth factor (EGF) signaling pathway, Ras and Jak/STAT signaling pathway, PI3K-Akt pathway, wnt/-catenin signaling pathway, inflammation with NF-kB pathway, angiogenesis with the VEGF pathways, DNA damage response pathways with mitochondrial oxidative stress and ATM pathway [3]–[4].