Such aberrations may also induce aberrant expression profiles, as we have described for MEOX2 and TWIST1 and as we suggest for HDAC9, AhR and EVX1 at the 7p21 and 7p15 cytogenetic regions that are controlled by loss of histone trimethylation and participate in the progression and prognosis of NSCLC patients [45]. The gene discussed is TWIST1; the disease is non-small cell lung carcinoma.