However, prior to the present study, MEOX2 and TWIST1 overexpression, which are under the epigenetic control of H3K27me3, were not known to be involved in chemoresistance and poor prognosis in NSCLC, although EZH2-mediated trimethylation of H3K27 has been previously correlated with bronchoepithelial oncogenic transformation and evasion of apoptosis [47]. This evidence concerns the gene MEOX2 and non-small cell lung carcinoma.