These results support our hypothesis that the loss of H3K27me3 and the enrichment of H3K4me3, as well as H3K27Ac in some cases (Figure 5A–D) exceed the presence or absence of CNVs at 7p21 inducing overexpression of MEOX2 and TWIST1, associated to NSCLC patients prognosis. The gene discussed is MEOX2; the disease is non-small cell lung carcinoma.