Furthermore, we demonstrated that altered MEOX2 and TWIST1 expression in NSCLC is dependent upon the histone marker H3K27me3, which is catalyzed under normal conditions by the histone methyltransferase EZH2, a component of the Polycomb-repressive complex 2 (PRC2) [42]. The gene discussed is TWIST1; the disease is non-small cell lung carcinoma.