We have previously confirmed this point of view by identifying promoter hypermethylation of DAPK as a predictive factor for locoregional control [16], and here, we further explored another potential prognostic marker, i,e., promoter hypermethylation of FHIT, as a useful predictor of both locoregional control and overall survival, in irradiated oral cancer patients. The gene discussed is FHIT; the disease is lip and oral cavity carcinoma.