DMD and neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan: The Largemyd mouse model of dystroglycanopathy, in which there are defects in the glycosylation of α-dystroglycan (a component of the dystrophin-associated glycoprotein complex) (Muntoni et al, 2004), has significantly more satellite cells than wild type control muscles, at 2–3 months of age (Ross et al, 2012).