Taken together our data demonstrate that SK1 and autocrine S1P are necessary for COX2 induction in colon epithelium; suggesting perhaps inhibition of SK1, as an upstream inducer of COX2, in colon epithelial cells may prove to be a valid therapeutic target, as well as provide more insight into the role for SK1 and COX2 in IBD. This evidence concerns the gene PTGS2 and inflammatory bowel disease.