Further, the gonococcal infection upregulated MAD1L1 mitotic arrest deficient-like 1 (encoding the MAD1 protein) by 1.4-fold and downregulated MAD2L1 mitotic arrest deficient-like 1 (encoding the MAD2 protein) by 0.7-fold (Fig. 5C). This evidence concerns the gene MXD1 and bacterial sexually transmitted disease.