As a translational comparison, the increases in the number of cynomolgus Tregs/mm3 induced by the low-dose IL-2 fusion proteins (Fig. 2C) are equivalent to the Tregs/mm3 in human GVHD patients treated daily with 1 × 106 IU/m2 Proleukin [20]. This evidence concerns the gene IL2 and graft versus host disease.