This makes our study unique as most data on BNP being of prognostic significance over and above echocardiographic abnormalities did not do the comprehensive phenotyping that we did and in particular did not screen for myocardial ischemia, which is known to independently increase BNP 4, 5, 6, 7, 16. The gene discussed is NPPB; the disease is myocardial ischemia.