APOE and neuroblastoma: Although there is some evidence for expression of leptin mRNA in the brain (Morash et al., 1999) and in a neuroblastoma cell line (Marwarha et al., 2011), we could not detect leptin expression in mice brain (wt, Tg2576, apoE3 or apoE4), neither in astrocytes nor hippocampal neurons from rat primary cultures, both in basal conditions or after treatment with Aβ1-42.