PRNP and colorectal cancer: For instance, in one of the first reports that tied PrPC to cancer biology, the overexpression of PrPC was observed to promote invasive and metastatic properties of gastric cancer cell lines (Pan et al., 2006), and a more recent report suggested that high PrPC levels can be predictive of disease recurrence in colorectal cancers (Antonacopoulou et al., 2010).