The notion of an involvement of PrPC in the morphogenetic program underlying EMT emerged recently from several independent strands of investigation, including (1) observations in cancer paradigms that predominantly see a role of PrPC as a promoter of cellular invasiveness and malignancy; (2) morpholino-based manipulations of PrP levels undertaken in zebrafish; (3) a subset of available PrP protein–protein interaction data; and (4) commonalities between PrP and the subbranch of ZIP transporters from which it descended. Here, PRNP is linked to cancer.