APC and inflammatory bowel disease: To our knowledge, this is the first study to provide an in-depth evaluation of the role and function of Prom1. Given the strong influence of Prom1 presence and control of progression of inflammation and development of dysplastic crypts, as well as limiting tumorigenesis in the presence of Apc loss, one may hypothesize that PROM1 may have a role in inflammation-mediated colonic dysplasia such as that which occurs not infrequently in long-standing IBD of the colon in humans.