In organ transplant recipients, who suffer from active HCMV diseases, the transcription of IL-10 and transforming growth factor (TGF)-β is significantly increased, while the expression of interferon (IFN)-γ is reduced, suggesting a shift from pro-inflammatory TH1 to the immune-tolerogenic TH2 response and resemble that found in CRC (45, 46). The gene discussed is TGFB1; the disease is colorectal carcinoma.