Furthermore, the interaction of active Rac1 with IQ motif containing GTPase activating protein 1 (IQGAP1), which is associated with a disassembly of E-cadherin-mediated adherens junctions, has been shown to destabilize E-cadherin-mediated cell-cell adhesion in pancreatic carcinoma cells. The gene discussed is CDH1; the disease is exocrine pancreatic carcinoma.