The clinical study carried out by Turemen et al (29) observed not only an elevation of several inflammation indicators, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and CRP, in patients with SH, but also a positive correlation of FMD between these inflammation factors, indicating that low grade chronic inflammation may be one of the factors that can promote endothelial dysfunction in SH. The gene discussed is TNF; the disease is endothelial dysfunction.