FMR1 and fragile X-associated tremor/ataxia syndrome: We obtained samples from FXTAS patient brains, and compared FMRP levels to the controls, finding a decrement in FMRP immunoreactivity in two of the three samples tested, though the number of samples evaluated was not sufficient to discern a significant difference when the two youngest control samples were excluded (cortex: t = 2.161, df = 9, NS; cerebellum: t = 1.793, df = 9, NS; control n = 8, FXTAS n = 3; Figures 4A–C).