FMR1 and fragile X-associated tremor/ataxia syndrome: Impaired FMRP expression in FXTAS model mice and patients have been described previously (Tassone et al., 2000a; Kenneson et al., 2001; Entezam et al., 2007; Qin et al., 2011; Iliff et al., 2013; Ludwig et al., 2014; Pretto et al., 2014).