TLR3 and dengue disease: TLR3-mediated innate and inflammatory responses were demonstrated to be protective against HIV, CMV and Dengue virus infections, while TLR3 stimulation results in detrimental disease outcomes in Influenza A virus and Punta Toro virus infections (Tabeta et al, 2004; Goffic et al, 2006; Gowen et al, 2006; Suh et al, 2007; Nasirudeen et al, 2011).