ELL3 and colorectal cancer: The data sets we utilized included coupled RNA-Seq and PolII ChIP-Seq data generated, in one instance, in a colorectal cancer cell line engineered to carry a doxycyclin-inducible shRNA targeting β-catenin, which allows for complete and specific blocking of the—in these cells constitutively active—Wnt pathway (12); in the other instance in mouse ES cells after shRNA-mediated knock-down of the RNA PolII elongation factor Ell3 (11).