Mutations in the p53 gene arise in >50% of all human cancers (Hollstein et al. 1991; Levine et al. 1991), and individuals with germline mutations in the TP53 gene develop Li-Fraumeni syndrome, a disorder that increases the risk of developing many different cancers, especially in children and young adults (Malkin 2011). This evidence concerns the gene TP53 and Li-Fraumeni syndrome.