PTEN and T-cell leukemia: PTEN, CDK6, CCNDs, RB, and dominant-negative Ikaros isoform expression has been previously shown to be altered in human T-cell leukemias/lymphomas (Chilosi et al. 1998; Sun et al. 1999; Hatta and Koeffler 2002; Sicinska et al. 2003; Maser et al. 2007; Li et al. 2008; Gutierrez et al. 2009).