PRKDC and neoplasm: ATM is the central mobilizer of the cellular response to DNA DSBs,37 is crucial for HR pathway,38 and ATM inhibition has been known to translate into effective radiosensitization.38 Similarly, inhibitors of the enzyme DNA-PKcs have been shown to augment the tumor radiosensitivity.39,40 Hence, inhibition of both these key proteins by zerumbone is an attractive attribute to its radiosensitizing potential, and could be a possible mechanism underlying the delayed resolution of γH2AX foci.