Another salient, but also highly variable, result of overexpression of LRRK2 in neurons and cell lines alike is the development of skein-like LRRK2 aggregates.45–47 These features have never been observed in cells in the brain of even LRRK2 transgenic (Tg) animals that overexpress LRRK2 many fold above endogenous levels, much less observed in normal rodent brain or human healthy and PD brain.48–50 Yet, many studies have prioritized observations involving LRRK2 aggregation resulting from overexpression. Here, LRRK2 is linked to Parkinson disease.