Because the formation of HVMPs in hPSC/OP9 coculture was closely followed by the development of HE and blood progenitors, we supplemented our cultures with SCF, TPO, IL-6, and IL-3 hematopoietic cytokines in addition to VEGF and FGF2, starting from day 4 of differentiation. Here, IL3 is linked to hereditary elliptocytosis.