More recently, in a combined analysis of BE and EAC cases, the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) identified susceptibility SNPs within CRTC1 and BARX1, and near FOXP1. 12The last 2 of these genes are known to be involved in esophageal development.15, 16. This evidence concerns the gene CRTC1 and esophageal adenocarcinoma.