Leukocytes—well-appreciated players in atherosclerosis and myocardial infarction (Drechsler et al., 2010, Dutta et al., 2012)—represent a main source of ALOX5-derived lipid mediators under pathophysiological conditions such as sustained inflammation in atherosclerosis (Spite and Serhan, 2010). The gene discussed is ALOX5; the disease is atherosclerosis.