ALOX5 and myocardial infarction: Intriguingly, evidence from genome-wide association studies (GWASs) revealed a robust association between single nucleotide polymorphisms (SNPs) of ALOX5 and of 5-lipoxygenase activating protein (FLAP) with the risk of myocardial infarction, obesity, and stroke (Helgadottir et al., 2004, Mehrabian et al., 2005, Peters-Golden and Henderson, 2007).