However, it is appropriate to issue certain caveats when trying to extrapolate mouse data to humans, since mouse models have limitations for the following reasons: mice have a different lipoprotein profile when compared to humans, with HDL being the major lipoprotein fraction in plasma; they do not express cholesteryl ester transfer protein in plasma; and they do not develop atherosclerosis when fed a high-cholesterol diet. The gene discussed is CETP; the disease is atherosclerosis.