In doing so, the same alterations in p19 and p27 (all cell lines) or cyclin A and cyclin B (KTC-26 cells), as has been induced in the control experiments, were also induced when RAD001 was added for 1 day to the RCC cells pre-treated with sunitinib (Fig.6, 1 day). Here, CCNA2 is linked to renal cell carcinoma.