Since the dermatitis and inflammatory phenotype were shown to be TNF dependent, and because the only TNF signaling output that was aberrantly increased in the absence of SHARPIN was cell death, we previously proposed TNF/TNFR1-mediated cell death to be causative of the cpdm phenotype (Gerlach et al., 2011). Here, TNFRSF1A is linked to skin disorder.