Chronic proliferative dermatitis mutation (cpdm) mice are deficient in SHARPIN (Sharpincpdm/cpdm: henceforth referred to as Shpnm/m; protein: SHARPIN) and develop dermatitis, multi-organ pathology and an immunological phenotype including disrupted lymphoid architecture, splenomegaly, liver inflammation and a loss of Peyer's patches in the gut (HogenEsch et al., 1993, 1999; Seymour et al., 2007). The gene discussed is SHARPIN; the disease is skin disorder.