Ikeda et al. reported cleaved caspase-3-positive keratinocytes in 10-week-old Shpnm/m mice (Ikeda et al., 2011), and we found cleaved caspase-3-positive cells were already present in the epidermis of 3-week-old Shpnm/m mice, indicating that apoptosis is an early event in the dermatitis and occurs before significant hyperplasia (Figure 2C). Here, CASP3 is linked to skin disorder.