PRKDC and dementia: Therefore, in this study, we defined the population variation in oxidative stress (lipid peroxidation) and the neuronal DDR (γH2AX and DNA‐PKcs) in the frontal association neocortex of CFAS cases with low levels of Alzheimer‐type pathology, pre‐selected only by being at low (0–II) Braak and Braak neurofibrillary tangle stage and investigated the relationship to dementia status.