Similar to the inflammatory phenotype observed in monocytes/macrophages from PD and ALS patients, studies addressing the characterisation of peripheral blood monocytes/macrophages of AD patients have shown that these cells display an increased M1 phenotype, with increased expression of chemokine receptors CCR2 and CXCR1 [87,88], and stronger production of inflammatory cytokines, including IL-1β, IL-6 and IL-23 [88,89]. This evidence concerns the gene CCR2 and amyotrophic lateral sclerosis.