To address the relevance of the different CD4+ T-cell phenotypes in AD, the same authors generated Aβ-specific CD4+ T-cells by immunisation of WT mice with Aβ and a TLR agonist, and then polarised them in vitro towards Th1, Th2 or Th17, which were then adoptively transferred into mice with AD. The gene discussed is CD4; the disease is Alzheimer disease.