In our series, there is a large difference in cancer size, gross appearance, lymph node metastasis, lymphovascular invasion, depth of invasion, and stage between the early and late recurrence groups, and patients with CD44 and vimentin, and loss of E-cadherin and β-catenin expression, have a higher tendency towards early recurrence. Here, CD44 is linked to metastatic malignant neoplasm in the lymph nodes.