The objective of this study was to assess whether forced RBM5 expression in lung adenocarcinoma cell line A549 cells and A549 xenografts could suppress the expression of EGFR, which would suggest that one of the mechanisms of potential tumor suppressor activity of RBM5 in NSCLC is initiated via the inactivation or inhibition of EGFR. Here, RBM5 is linked to lung adenocarcinoma.