These observations draw our interest in regard to the relationship between RBM5 and EGFR. We conducted a series of investigations to clarify the relationship between RBM5 and an important regulator of cell proliferation, EGFR. We detected RBM5 and EGFR expression in 120 paired resected NSCLC tumor tissues and adjacent normal tissues in a previous study, which suggested that the RBM5 expression was negatively correlated with the expression of EGFR in NSCLC tissues[22]. Here, RBM5 is linked to neoplasm.