In the last decades, new therapies have emerged, based on the knowledge of CFTR dysfunction and airway CF microbiome, such as targeting CFTR replacement, stimulation of alternative chloride channels, inhibition of sodium absorption, and airway rehydration, in order to avoid sputum accumulation and, consequently, the establishment of bacterial infections [3,4,5,12]. Here, CFTR is linked to cystic fibrosis.