This would also be consistent with our finding that adjustment for body mass index substantially reduced the associations between socioeconomic position and C-reactive protein, interleukin-6, proinsulin and leptin, emphasizing an important mediating role of body fatness in the association between socioeconomic position over the life course and novel CHD risk factors in later life; consistent with observations in the 1958 British Birth Cohort [35], and The Framingham Offspring Study [19]. Here, INS is linked to coronary artery disorder.