To discover early diagnostic and prognostic predictors in stage III melanoma, similar serum proteomic analyses were carried out by Findeisen et al [21] and by Verdoliva V et al [22], who underlined the role of serum amyloid A, a2macroglobulin, Apolipoprotein-E and Apolipoprotein-A1. The gene discussed is APOA1; the disease is melanoma.