Other potential cellular component are PXK, implicated in epidermal growth factor receptor endosome trafficking and in hormone related cancer risk [46], [47], TBC1D23 which is involved in microsatellite instability cancers [48], FAM150A with unknown function in vivo but reported as hyper methylated in aggressive clear cell carcinomas [49]. The gene discussed is ALKAL1; the disease is clear cell adenocarcinoma.